Pathogenic Gene Variants in Celiac Disease.

Celiac disease (CD) is an autoimmune disorder with both environmental and genetic risk factors. CD manifests itself when food containing gluten is eaten. It causes malabsorption by damaging the villi in the small intestine. This leads to the question: How do gene variants lead to the pathogenesis of Celiac disease? Other studies include genome-wide association studies to recognize more genetic risk factors associated with CD. This paper reviews how gene variants show a risk for CD and lead to the development of CD. It will show the significance of looking at how certain genes can change our body functions to alter a big part of our digestive system and how it can help us discover other genes possibly related to celiac disease. [ABSTRACT FROM AUTHOR]