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The role of lncRNA NEAT1 in human cancer chemoresistance.

Authors :
Long, Feng
Li, Xue
Pan, Jingyu
Ye, Hailin
Di, Cuixia
Huang, Yong
Li, Jiawei
Zhou, Xuan
Yi, Huiyi
Huang, Qiaozhen
Si, Jing
Source :
Cancer Cell International; 7/5/2024, Vol. 24 Issue 1, p1-13, 13p
Publication Year :
2024

Abstract

Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become an urgent problem to be solved in the field of cancer chemotherapy. Therefore, it is very important to deeply study and analyze the mechanism of cancer chemotherapy resistance and its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) has been shown to be closely associated with chemotherapy resistance in cancer. NEAT1 induces cancer cell resistance to chemotherapeutic drugs by regulating cell apoptosis, cell cycle, drug transport and metabolism, DNA damage repair, EMT, autophagy, cancer stem cell characteristics, and metabolic reprogramming. This indicates that NEAT1 may be an important target to overcome chemotherapy resistance and is expected to be a potential biomarker to predict the effect of chemotherapy. This article summarizes the expression characteristics and clinical characteristics of NEAT1 in different cancers, and deeply discusses the regulatory role of NEAT1 in cancer chemotherapy resistance and related molecular mechanisms, aiming to clarify NEAT1 as a new target to overcome cancer chemotherapy resistance and the feasibility of chemotherapy sensitizers, with a view to providing a potential therapeutic direction for overcoming the dilemma of cancer resistance in the future. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14752867
Volume :
24
Issue :
1
Database :
Complementary Index
Journal :
Cancer Cell International
Publication Type :
Academic Journal
Accession number :
178295620
Full Text :
https://doi.org/10.1186/s12935-024-03426-x