A comprehensive framework for stochastic calibration and sensitivity analysis of large-scale groundwater models.

We introduce a comprehensive and robust theoretical framework and operational workflow that can be employed to enhance our understanding, modeling and management capability of complex heterogeneous large-scale groundwater systems. Our framework encapsulates key components such as the three-dimensional nature of groundwater flows, river–aquifer interactions, probabilistic reconstruction of three-dimensional spatial distributions of geomaterials and associated properties across the subsurface, multi-objective optimization for model parameter estimation through stochastic calibration, and informed global sensitivity analysis (GSA). By integrating these components, we effectively consider the inherent uncertainty associated with subsurface system characterizations as well as their interactions with surface waterbodies. The approach enables us to identify parameters impacting diverse system responses. By employing a coevolutionary optimization algorithm, we ensure efficient model parameterization, facilitating simultaneous and informed optimization of the defined objective functions. Additionally, estimation of parameter uncertainty naturally leads to quantification of uncertainty in system responses. The methodology is designed to increase our knowledge of the dynamics of large-scale groundwater systems. It also has the potential to guide future data acquisition campaigns through an informed global sensitivity analysis. We demonstrate the effectiveness of our proposed methodology by applying it to the largest groundwater system in Italy. We address the challenges posed by the characterization of the heterogeneous spatial distribution of subsurface attributes across large-scale three-dimensional domains upon incorporating a recent probabilistic hydrogeological reconstruction specific to the study case. The system considered faces multiple challenges, including groundwater contamination, seawater intrusion, and water scarcity. Our study offers a promising modeling strategy applicable to large-scale subsurface systems and valuable insights into groundwater flow patterns that can then inform effective system management. [ABSTRACT FROM AUTHOR]