Editorial: Necroptosis: from bench to bedside.

This article, titled "Editorial: Necroptosis: from bench to bedside," explores the role of necroptosis, a programmed cell death pathway, in human diseases and potential therapeutic approaches. The article highlights the interactions between necroptosis and the immune system, as well as its involvement in inflammatory diseases such as skin inflammation, Inflammatory Bowel Disease, pancreatitis, and Multiple Sclerosis. The authors also discuss the regulation of necroptosis by TNF Receptor Interacting Kinase 1 (RIPK1) and the potential for targeting RIPK1 in the treatment of various inflammatory conditions. The article includes in-depth reviews of the pathophysiological mechanisms of necroptosis in Idiopathic Inflammatory Myopathies and gastrointestinal diseases, as well as the role of RIPK1 in neuroinflammation and neurodegenerative diseases. The authors conclude by emphasizing the need for further research and the development of therapeutic strategies targeting the necroptotic machinery. [Extracted from the article]