Findings from University of Arizona Advance Knowledge in Oncology (Extracellular signals induce dynamic ER remodeling through aTAT1-dependent microtubule acetylation).

A recent study conducted at the University of Arizona has explored the dynamic changes in the endoplasmic reticulum (ER) morphology and its role in maintaining cellular homeostasis. The researchers discovered that extracellular signals can induce ER remodeling through a process involving microtubule acetylation. This remodeling is mediated by the TAK1/aTAT1 pathway, which promotes cell survival by downregulating a proapoptotic effector called BOK. These findings suggest that the TAK1/aTAT1 pathway could be a potential target for addressing ER stress and dysfunction. [Extracted from the article]