Karolinska Institute Researcher Targets Medulloblastoma (Mdb-34. Lithium And Radiation Reduce Tumour Growth in Group 3 Medulloblastoma).

A recent report discusses research on medulloblastoma, the most common high-grade pediatric brain tumor. The study focuses on Group 3 medulloblastoma, which has a poor prognosis and is associated with permanent complications from current treatments. The researchers investigated the effects of lithium and radiation on tumor growth in vitro and in vivo, finding that lithium, alone and in combination with radiation, significantly reduced tumor growth. The study also identified Klf4 as a potential effector of lithium's mechanism of action. This research provides insights into potential preventive treatment strategies for ameliorating the side effects of current treatments for Group 3 medulloblastoma. [Extracted from the article]