Research Reports from Shanxi University Provide New Insights into Cancer (The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway).

A recent research report from Shanxi University in China explores the use of a compound called C2 in enhancing the effectiveness of oxaliplatin, a chemotherapy drug used in cancer treatment. The study found that C2 was able to reverse resistance to oxaliplatin in colon cancer cells and inhibit tumor growth. Additionally, C2 was found to induce autophagy, a cellular process that can contribute to chemotherapy resistance. The researchers suggest that C2 acts through the PI3K/AKT/mTOR signaling pathway and p53 to induce autophagy and enhance the cell death caused by oxaliplatin. [Extracted from the article]