Research from State Key Laboratory in Lung Cancer Provides New Insights (AKAP95 regulates ubiquitination and degradation of cyclin Ds/Es, influencing the G1/S transition of lung cancer cells).

A recent report from the State Key Laboratory discusses research on lung cancer. The study focuses on the role of A-kinase anchoring protein 95 (AKAP95) in regulating the expression of cyclin D and E proteins, which affects the cell cycle progression in lung cancer cells. The researchers found that AKAP95 forms a complex with Connexin 43 (Cx43) and associates with cyclins D1 and E1 during the G1 phase, leading to the formation of protein complexes that translocate to the nucleus. This process ultimately impacts cell cycle progression in lung cancer cells. The findings suggest that AKAP95 may facilitate the nuclear transport of cyclins D1 and E1 and regulate their degradation through ubiquitination. [Extracted from the article]