Investigators at Huazhong University of Science and Technology Report Findings in Liposomes (Rapamycin Liposomes Targeted To Lymph Nodes Inhibit Dendritic Cell Maturation for the Treatment of Transplant Rejection).

Researchers at Huazhong University of Science and Technology in Wuhan, China have developed a new method for treating transplant rejection. The researchers created liposome-encapsulated rapamycin (LNP@rapa), which selectively targets lymph nodes and inhibits the maturation of dendritic cells (DCs) within these nodes. This approach has been shown to reduce inflammatory cytokine secretion and significantly prolong graft survival in mouse transplantation models. The study introduces an innovative strategy for impeding DC maturation and offers a promising approach to address transplant rejection. [Extracted from the article]