Findings on Epilepsy Detailed by Investigators at University of Washington (Development of a Novel Dosing Paradigm To Model Diazepam Rescue Therapy In Preclinical Seizure and Epilepsy Models).

A recent report from the University of Washington discusses the development of a new dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models. Diazepam is commonly used as an immediate-use antiseizure rescue therapy for people with epilepsy. However, there is limited understanding of how intermittent rescue therapy affects disease progression due to a lack of suitable preclinical models. The researchers developed a novel repeat rescue therapy dosing paradigm in rats that mimics drug concentrations and accumulation seen in humans, providing a preclinical tool to study the impact of benzodiazepine rescue therapy on seizure-cluster biology in rodent models of epilepsy. This study allows for further investigation into how diazepam works in the brains of individuals who use it for seizure clusters. [Extracted from the article]