New HIV/AIDS Research Reported from Islamic Azad University Tehran North Branch [Preparation of Imidodicarbonic diamide Derivatives by Microwave Method Using Layered Double Hydroxides (LDHs), as an Efficient Catalyst and Evaluation of their...].

A new study conducted at Islamic Azad University Tehran North Branch in Iran explores the use of layered double hydroxides (LDHs) as a catalyst for the synthesis of imidodicarbonate diamide derivatives (biurets) under microwave conditions. The researchers found that this method reduced the need for organic solvents, decreased reaction times, and increased product yields, aligning with the principles of green chemistry and environmental protection. Additionally, three of the biurets synthesized showed moderate inhibitory activity against HIV-1, making them potential candidates for further investigation. Docking analysis studies were also conducted to understand the mechanism of action of these compounds on the virus protease enzyme. [Extracted from the article]