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FSGS Recurrence Collaboration: Report of a Symposium.

Authors :
Gipson, Debbie S.
Wang, Chia-shi
Salmon, Eloise
Gbadegesin, Rasheed
Naik, Abhijit
Sanna-Cherchi, Simone
Fornoni, Alessia
Kretzler, Matthias
Merscher, Sandra
Hoover, Paul
Kidwell, Kelley
Saleem, Moin
Riella, Leonardo
Holzman, Lawrence
Jackson, Annette
Olabisi, Opeyemi
Cravedi, Paolo
Freedman, Benjamin Solomon
Himmelfarb, Jonathan
Vivarelli, Marina
Source :
Glomerular Diseases (2673-3633); 2024, Vol. 4 Issue 1, p1-10, 10p
Publication Year :
2024

Abstract

This document is a report of a symposium on FSGS recurrence, a kidney disease characterized by podocyte injury and depletion. The report discusses the incidence of FSGS across different age groups and its contribution to nephrotic syndrome cases. It highlights the varying treatment protocols and the ongoing genetic studies to understand the disease. The text also explores different approaches and technologies used to study FSGS, including flow cytometric analysis, single-cell technologies, proteomic analysis, and the development of organoids and glomerular spheroids as models. The document emphasizes the need for further research and the challenges in conducting clinical trials for patients with recurrent FSGS. It also mentions the RESOLVE study as an example of collaborative efforts in gathering data on the disease. The potential of functional tools like human organoids in pre-clinical research is also discussed. [Extracted from the article]

Details

Language :
English
ISSN :
26733633
Volume :
4
Issue :
1
Database :
Complementary Index
Journal :
Glomerular Diseases (2673-3633)
Publication Type :
Academic Journal
Accession number :
178215184
Full Text :
https://doi.org/10.1159/000535138