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Immune response to SARS-CoV-2 variants after immunization with different vaccines in Mexico.
- Source :
- Epidemiology & Infection; 2024, Vol. 152, p1-9, 9p
- Publication Year :
- 2024
-
Abstract
- There is limited information on the antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in subjects from developing countries with populations having a high incidence of co-morbidities. Here, we analysed the immunogenicity of homologous schemes using the ChAdOx1-S, Sputnik V, or BNT162b2 vaccines and the effect of a booster dose with ChAdOx1-S in middle-aged adults who were seropositive or seronegative to the SARS-CoV-2 spike protein before vaccination. The study was conducted post-vaccination with a follow-up of 4 months for antibody titre using enzyme-linked immunosorbent assay (ELISA) and pseudovirus (PV) neutralization assays (PNAs). All three vaccines elicited a superior IgG anti-receptor-binding domain (RBD) and neutralization response against the Alpha and Delta variants when administered to individuals with a previous infection by SARS-CoV-2. The booster dose spiked the neutralization activity among individuals with and without a prior SARS-CoV-2 infection. The ChAdOx1-S vaccine induced weaker antibody responses in infection-naive subjects. A follow-up of 4 months post-vaccination showed a drop in antibody titre, with about 20% of the infection-naive and 100% of SARS-CoV-2 pre-exposed participants with detectable neutralization capacity against Alpha pseudovirus (Alpha-PV) and Delta PV (Delta-PV). Our observations support the use of different vaccines in a country with high seroprevalence at the vaccination time. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09502688
- Volume :
- 152
- Database :
- Complementary Index
- Journal :
- Epidemiology & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 178212412
- Full Text :
- https://doi.org/10.1017/S0950268824000219