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Machine Learning Approach for Cardiovascular Death Prediction among Nonalcoholic Steatohepatitis (NASH) Liver Transplant Recipients.
- Source :
- Healthcare (2227-9032); Jun2024, Vol. 12 Issue 12, p1165, 17p
- Publication Year :
- 2024
-
Abstract
- Cardiovascular disease is the leading cause of mortality among nonalcoholic steatohepatitis (NASH) patients who undergo liver transplants. In the present study, machine learning algorithms were used to identify important risk factors for cardiovascular death and to develop a prediction model. The Standard Transplant Analysis and Research data were gathered from the Organ Procurement and Transplantation Network. After cleaning and preprocessing, the dataset comprised 10,871 patients and 92 features. Recursive feature elimination (RFE) and select from model (SFM) were applied to select relevant features from the dataset and avoid overfitting. Multiple machine learning algorithms, including logistic regression, random forest, decision tree, and XGBoost, were used with RFE and SFM. Additionally, prediction models were developed using a support vector machine, Gaussian naïve Bayes, K-nearest neighbors, random forest, and XGBoost algorithms. Finally, SHapley Additive exPlanations (SHAP) were used to increase interpretability. The findings showed that the best feature selection method was RFE with a random forest estimator, and the most critical features were recipient and donor blood type, body mass index, recipient and donor state of residence, serum creatinine, and year of transplantation. Furthermore, among all the outcomes, the XGBoost model had the highest performance, with an accuracy value of 0.6909 and an area under the curve value of 0.86. The findings also revealed a predictive relationship between features and cardiovascular death after liver transplant among NASH patients. These insights may assist clinical decision-makers in devising strategies to prevent cardiovascular complications in post-liver transplant NASH patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARDIOVASCULAR disease related mortality
NON-alcoholic fatty liver disease
RANDOM forest algorithms
RISK assessment
POSTOPERATIVE care
PATIENTS
TRANSPLANTATION of organs, tissues, etc.
DEATH
BODY mass index
CREATININE
RECEIVER operating characteristic curves
LOGISTIC regression analysis
MEDICAL care
KRUSKAL-Wallis Test
ORGAN donation
CAUSES of death
CARDIOVASCULAR diseases risk factors
DECISION making
DESCRIPTIVE statistics
CHI-squared test
SUPPORT vector machines
CONCEPTUAL structures
MACHINE learning
COMPARATIVE studies
LIVER transplantation
ALGORITHMS
Subjects
Details
- Language :
- English
- ISSN :
- 22279032
- Volume :
- 12
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Healthcare (2227-9032)
- Publication Type :
- Academic Journal
- Accession number :
- 178194720
- Full Text :
- https://doi.org/10.3390/healthcare12121165