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V2CTx‑Au Nanostructures for Rapid Surface-Enhanced Raman Scattering Detection of Bacteria and Synergistic Photothermal/Photodynamic Therapy.
- Source :
- ACS Applied Nano Materials; 6/28/2024, Vol. 7 Issue 12, p14673-14683, 11p
- Publication Year :
- 2024
-
Abstract
- The misuse of antibiotics has led to the emergence of multidrug-resistant bacteria. There is an urgent need to explore methods to effectively kill bacteria without relying on antibiotics. In this paper, a vanadium carbide-based (V<subscript>2</subscript>CT<subscript>x</subscript>-Au) nanostructures was successfully synthesized by electrostatic self-assembly for the direct detection and killing of bacteria. The nanostructures could be directly used for label-free surface-enhanced Raman spectroscopy detection of bacteria without tedious processing. Photothermal detection demonstrated that the temperature of the V<subscript>2</subscript>CT<subscript>x</subscript>-Au nanostructures can increase above 50 °C within just 200 s, and the photothermal conversion efficiency of the material is 37.82%. Reactive oxygen species detection experiments showed that the V<subscript>2</subscript>CT<subscript>x</subscript>-Au nanostructures can produce the O<subscript>2</subscript><superscript>·–</superscript> and <superscript>1</superscript>O<subscript>2</subscript>. Combined with SEM images of the bacteria, the results showed that V<subscript>2</subscript>CT<subscript>x</subscript>-Au nanostructures produced photothermal therapy antibacterial effects under 808 nm laser irradiation and exhibited photodynamic therapy synergistic antibacterial properties. The survival rates of Escherichia coli (E. coli) and extended-spectrum β-lactamase Escherichia coli (ESBL- E. coli) were 6.88 and 1.58%, respectively. In addition, cytotoxicity experiments and hemolytic tests showed that the prepared V<subscript>2</subscript>CT<subscript>x</subscript>-Au nanostructures exhibited good biocompatibility. This study provides a feasible route for the label-free and rapid detection of bacteria and rapid sterilization without antibiotics, which can help solve the problem of bacterial infection, especially drug-resistant bacteria. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 25740970
- Volume :
- 7
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- ACS Applied Nano Materials
- Publication Type :
- Academic Journal
- Accession number :
- 178179820
- Full Text :
- https://doi.org/10.1021/acsanm.4c02222