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Acute Retinal Necrosis Associated with Pseudorabies Virus Infection: A Case Report and Literature Review.

Authors :
Xu, Guangcan
Hou, Baoke
Xue, Cuiping
Xu, Quangang
Qu, Linghui
Hao, Xiaolu
Liu, Ying
Wang, Dajiang
Li, Zhaohui
Jin, Xin
Source :
Ocular Immunology & Inflammation; Jul2024, Vol. 32 Issue 5, p594-601, 8p
Publication Year :
2024

Abstract

To analyze a case of acute retinal necrosis (ARN) associated with pseudorabies virus (PRV) infection and discusses the clinical characteristics of PRV-induced ARN (PRV-ARN). Case report and literature review of ocular features in PRV-ARN. A 52-year-old female diagnosed with encephalitis presented with bilateral vision loss, mild anterior uveitis, vitreous opacity, occlusive retinal vasculitis, and retinal detachment in her left eye. The result of metagenomic next-generation sequencing (mNGS) indicated that both cerebrospinal fluids and vitreous fluid tested positive for PRV. PRV, a zoonosis, can infect both humans and mammals. Patients affected with PRV may experience severe encephalitis and oculopathy, and the infection has been associated with high mortality and disability. ARN is the most common ocular disease, which develops rapidly following encephalitis and is characterized by five figures: bilateral onset, rapid progression, severe visual impairment, poor response to systemic antiviral drugs, and an unfavorable prognosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09273948
Volume :
32
Issue :
5
Database :
Complementary Index
Journal :
Ocular Immunology & Inflammation
Publication Type :
Academic Journal
Accession number :
178176328
Full Text :
https://doi.org/10.1080/09273948.2023.2181188