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Long‐term survival after immunotherapy for uncontrolled locally advanced temporal bone squamous cell carcinoma followed by chemoradiotherapy: A case report.
- Source :
- Precision Radiation Oncology; Jun2024, Vol. 8 Issue 2, p99-105, 7p
- Publication Year :
- 2024
-
Abstract
- Temporal bone squamous cell carcinoma (TBSCC) is a rare and invasive malignant tumor. The common predisposing factors include a history of local radiotherapy and chronic suppurative otitis media. The current treatment approach for TBSCC primarily involves surgery, followed by adjuvant radiotherapy and chemotherapy, based on T staging and high‐risk factors. Although patients with early‐stage TBSCC have a high survival rate after treatment, the majority of patients are diagnosed in the intermediate to advanced stages, with extensive tumor involvement, posing challenges for surgical intervention. Definitive chemoradiotherapy (CRT) serves as a viable alternative for unresectable tumors. Constraints in administering curative radiation doses, due to the tolerance of surrounding organs, can lead to uncontrolled tumor growth. Although programmed cell death 1 inhibitors have demonstrated efficacy in head and neck squamous cell carcinoma and cutaneous squamous cell carcinoma, their application in TBSCC remains underexplored. Herein, we report a case of a 47‐year‐old man diagnosed with unresectable advanced and localized TBSCC. Following inadequate tumor control with primary chemoradiotherapy, immunotherapy was initiated, resulting in disease remission within a follow‐up period of > 4 years. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of antineoplastic agents
THERAPEUTIC use of monoclonal antibodies
SQUAMOUS cell carcinoma
BIOPSY
CANCER relapse
IMMUNOTHERAPY
ADJUVANT treatment of cancer
BONE tumors
CHEMORADIOTHERAPY
TREATMENT effectiveness
DISEASE remission
MAGNETIC resonance imaging
POSITRON emission tomography computed tomography
CANCER chemotherapy
PROGRAMMED cell death 1 receptors
PROGRESSION-free survival
TUMOR classification
RADIATION doses
Subjects
Details
- Language :
- English
- ISSN :
- 23987324
- Volume :
- 8
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Precision Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 178162036
- Full Text :
- https://doi.org/10.1002/pro6.1233