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Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach.
- Source :
- Children; Jun2024, Vol. 11 Issue 6, p737, 12p
- Publication Year :
- 2024
-
Abstract
- This study assesses the utility of early biomarkers—5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)—for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD). Due to the risks associated with invasive diagnostics, such as right heart catheterization, non-invasive biomarkers provide a safer alternative for early PH detection. This cohort-based study utilized blood and urine samples to measure 5-HIAA and IGF-1 levels via enzyme immunoassays. Our findings revealed significant changes in 5-HIAA concentrations across various biological matrices, supporting its potential as a diagnostic tool. Specifically, altered levels in urine and plasma reflect its role in serotonin metabolism and vascular remodeling in PH. IGF-1 levels were notably reduced in plasma, suggesting its involvement in PH pathophysiology. ROC analysis confirmed the diagnostic efficacy of these biomarkers, particularly 5-HIAA's high specificity and sensitivity. In conclusion, 5-HIAA and IGF-1 levels correlate well with PH, underscoring their diagnostic value for early PH detection in children with CHD. [ABSTRACT FROM AUTHOR]
- Subjects :
- PULMONARY hypertension diagnosis
CONGENITAL heart disease
PREDICTIVE tests
RECEIVER operating characteristic curves
DATA analysis
RESEARCH funding
PULMONARY hypertension
ENZYME-linked immunosorbent assay
MANN Whitney U Test
INDOLE compounds
LONGITUDINAL method
URINALYSIS
STATISTICS
SOMATOMEDIN
IMMUNOASSAY
SEROTONIN
VASCULAR remodeling
DATA analysis software
CONFIDENCE intervals
BIOMARKERS
SENSITIVITY & specificity (Statistics)
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 178159713
- Full Text :
- https://doi.org/10.3390/children11060737