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Association between COVID-19 and the Risk of Vascular Dementia: A Mendelian Randomisation Study of the Potential Cognitive Sequela of COVID-19.
- Source :
- Behavioral Sciences (2076-328X); Jun2024, Vol. 14 Issue 6, p465, 13p
- Publication Year :
- 2024
-
Abstract
- A growing body of observational studies and Mendelian Randomisation analyses suggest an increased risk of Alzheimer's disease and dementia following COVID-19 infection. However, evidence on the potential association between COVID-19 and vascular dementia, which is plausible given the vascular complications of COVID-19 infection, is still limited. In this study, we conducted a two-sample Mendelian Randomisation analysis to examine the potential causal relationship between COVID-19 phenotypes and the risk of vascular dementia, using summary data from large-scale GWASs. The two-sample Mendelian Randomisation analysis did not detect any significant associations of COVID-19 infection, COVID-19 hospitalisation, or critical COVID-19 with the risk of vascular dementia, with weighted average β values of −0.29 (95% CI: −0.84, 0.26; p = 0.301), −0.12 (95% CI: −0.36, 0.13; p = 0.345), and −0.07 (95% CI: −0.23, 0.09; p = 0.374), respectively. Our findings do not support the hypothesis that vascular dementia is one of the long-term sequelae of COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- VASCULAR dementia
DISEASE risk factors
ALZHEIMER'S disease
COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 2076328X
- Volume :
- 14
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Behavioral Sciences (2076-328X)
- Publication Type :
- Academic Journal
- Accession number :
- 178159484
- Full Text :
- https://doi.org/10.3390/bs14060465