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An Efficient and Eco-Friendly Procedure for Electrophilic Thiocyanation of Anilines and 1-(Substituted benzylidene)-2-phenyl Hydrazines.
- Source :
- Chemistry (2624-8549); Jun2024, Vol. 6 Issue 3, p476-488, 13p
- Publication Year :
- 2024
-
Abstract
- Thiocyanates form an important class of organic compounds commonly found in natural products that exhibit excellent antimicrobial activity. The electrophilic thiocyanation is one of the most effective methods of introducing a -SCN functional group to the parent organic molecule. In this work, we explored an eco-friendly and highly efficient method for thiocyanation of anilines and 1-(substituted benzylidene)-2-phenylhydrazines using commercially available N-bromoscuccinimide (NBS) and potassium thiocyanate (KSCN). The optimized protocol afforded thiocyanates with good regioselectivity and excellent yields in comparison to the available methods. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDRAZINES
ANILINE
HYDRAZINE
ORGANIC compounds
THIOCYANATES
Subjects
Details
- Language :
- English
- ISSN :
- 26248549
- Volume :
- 6
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Chemistry (2624-8549)
- Publication Type :
- Academic Journal
- Accession number :
- 178153182
- Full Text :
- https://doi.org/10.3390/chemistry6030027