Recent Studies from Taipei Medical University Add New Data to Ovarian Cancer (Active DNA Demethylase, TET1, Increases Oxidative Phosphorylation and Sensitizes Ovarian Cancer Stem Cells to Mitochondrial Complex I Inhibitor).

A recent study from Taipei Medical University explores the role of TET1, an active DNA demethylase, in ovarian cancer. The researchers found that TET1 reprogrammed the ovarian cancer epigenome, increased stem properties, and activated metabolic networks, particularly oxidative phosphorylation (OXPHOS). Contrary to the Warburg effect, TET1 increased energy production through OXPHOS rather than glycolysis. The study suggests that targeting metabolic interventions could be a novel strategy for treating ovarian cancer. [Extracted from the article]