Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity.

A recent study examined the neural basis of sound sensitivity in individuals with Fragile X syndrome (FXS), a genetic disorder that often leads to intellectual disability, anxiety, and sensory hypersensitivity. The researchers used scalp electroencephalography (EEG) to analyze brain activity in 36 individuals with FXS and 39 healthy controls. The results showed that individuals with FXS exhibited excessive activation in the frontal cortex and disruptions in gamma phase synchrony, which may contribute to auditory hypersensitivity. These findings could potentially inform the development of therapeutic strategies for FXS. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]