Catholic University of Korea Researchers Describe Research in Carcinomas (Discovery and Validation of Survival-Specific Genes in Papillary Renal Cell Carcinoma Using a Customized Next-Generation Sequencing Gene Panel).

Researchers from the Catholic University of Korea have conducted a study to identify and validate survival-specific genes in papillary renal cell carcinoma (PRCC), the second most common kidney cancer. Using machine learning, they analyzed data from 293 patients to derive genes associated with survival. They then validated these genes using DNA samples from 60 Korean PRCC patients. The study identified 40 survival-specific genes, 10 of which were validated in the Korean database. Three genes (BAP1, PCSK2, and SPATA13) showed survival specificity in both overall survival and disease-free survival. The researchers believe that these findings can provide insight into predicting the survival of PRCC patients and developing new treatments. [Extracted from the article]