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Maternal obesity and metabolic (dysfunction) associated fatty liver disease in pregnancy: a comprehensive narrative review.

Authors :
Leca, Bianca M.
Lagojda, Lukasz
Kite, Chris
Karteris, Emmanouil
Kassi, Eva
Randeva, Harpal S.
Kyrou, Ioannis
Source :
Expert Review of Endocrinology & Metabolism; Jul2024, Vol. 19 Issue 4, p335-348, 14p
Publication Year :
2024

Abstract

Obesity and metabolic-associated fatty liver disease (MAFLD) during pregnancy constitute significant problems for routine antenatal care, with increasing prevalence globally. Similar to obesity, MAFLD is associated with a higher risk for maternal complications (e.g. pre-eclampsia and gestational diabetes) and long-term adverse health outcomes for the offspring. However, MAFLD during pregnancy is often under-recognized, with limited management/treatment options. PubMed/MEDLINE, EMBASE, and Scopus were searched based on a search strategy for obesity and/or MAFLD in pregnancy to identify relevant papers up to 2024. This review summarizes the pertinent evidence on the relationship between maternal obesity and MAFLD during pregnancy. Key mechanisms implicated in the underlying pathophysiology linking obesity and MAFLD during pregnancy (e.g. insulin resistance and dysregulated adipokine secretion) are highlighted. Moreover, a diagnostic approach for MAFLD diagnosis during pregnancy and its complications are presented. Finally, promising relevant areas for future research are covered. Research progress regarding maternal obesity, MAFLD, and their impact on maternal and fetal/offspring health is expected to improve the relevant diagnostic methods and lead to novel treatments. Thus, routine practice could apply more personalized management strategies, incorporating individualized algorithms with genetic and/or multi-biomarker profiling to guide prevention, early diagnosis, and treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17446651
Volume :
19
Issue :
4
Database :
Complementary Index
Journal :
Expert Review of Endocrinology & Metabolism
Publication Type :
Academic Journal
Accession number :
178089570
Full Text :
https://doi.org/10.1080/17446651.2024.2365791