Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons.

Authors :: Papassotiropoulos, Andreas
de Quervain, Dominique J.-F.
Source :: Science Signaling; 6/25/2024, Vol. 17 Issue 842, p1-2, 2p
Publication Year :: 2024
Abstract: WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling, Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition. [ABSTRACT FROM AUTHOR]

Subjects :: NEUROPLASTICITY
HIPPO signaling pathway
SCAFFOLD proteins
MEMORY
PLUTO (Dwarf planet)
KINASES
HORIZON

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