PIK3CA‐related congenital haemangioma.

This article discusses a case study of a newborn male with a congenital haemangioma (CH), a rare benign vascular tumor present at birth. The CH showed rapid and partial involution over 6 months and was surgically excised without complications. Genetic analysis of the affected tissue revealed a pathogenic variant in the PIK3CA gene, which is associated with various cancers and non-malignant alterations. The patient also developed a nephroblastoma, but no PIK3CA mutations were detected in the renal tumor. This case highlights the importance of understanding the mechanisms involved in the development of benign or malignant tumors. [Extracted from the article]