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Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway.
- Source :
- BMC Oral Health; 6/21/2024, Vol. 24 Issue 1, p1-17, 17p
- Publication Year :
- 2024
-
Abstract
- Background: Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and oral infections, and recent research suggests a link between these pathogens and oral cancer initiation and progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns and treatment limitations. Methods: We synthesized and analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, and EDAX. Antioxidant and antimicrobial effectiveness were evaluated through DPPH, ABTS, and MIC assays, while the anticancer properties were assessed on KB oral squamous carcinoma cells. Results: ZnO-PIP NPs exhibited significant antioxidant activity and a MIC of 50 µg/mL against dental pathogens, indicating strong antimicrobial properties. Interaction analysis revealed high binding affinity with dental pathogens. ZnO-PIP NPs showed dose-dependent anticancer activity on KB cells, upregulating apoptotic genes BCL2, BAX, and P53. Conclusions: This approach offers a multifaceted solution to combatting both oral infections and cancer, showcasing their potential for significant advancement in oral healthcare. It is essential to acknowledge potential limitations and challenges associated with the use of ZnO NPs in clinical applications. These may include concerns regarding nanoparticle toxicity, biocompatibility, and long-term safety. Further research and rigorous testing are warranted to address these issues and ensure the safe and effective translation of ZnO-PIP NPs into clinical practice. [ABSTRACT FROM AUTHOR]
- Subjects :
- ZINC oxide
BIOFILMS
MOUTH tumors
DATA analysis
RESEARCH funding
APOPTOSIS
CELLULAR signal transduction
REVERSE transcriptase polymerase chain reaction
DESCRIPTIVE statistics
CELL lines
GENE expression
ONCOGENES
MOLECULAR structure
SPECTRUM analysis
ANTIOXIDANTS
ONE-way analysis of variance
STATISTICS
DATA analysis software
NANOPARTICLES
Subjects
Details
- Language :
- English
- ISSN :
- 14726831
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Oral Health
- Publication Type :
- Academic Journal
- Accession number :
- 178026878
- Full Text :
- https://doi.org/10.1186/s12903-024-04399-z