Image2Flow: A proof-of-concept hybrid image and graph convolutional neural network for rapid patient-specific pulmonary artery segmentation and CFD flow field calculation from 3D cardiac MRI data.

Computational fluid dynamics (CFD) can be used for non-invasive evaluation of hemodynamics. However, its routine use is limited by labor-intensive manual segmentation, CFD mesh creation, and time-consuming simulation. This study aims to train a deep learning model to both generate patient-specific volume-meshes of the pulmonary artery from 3D cardiac MRI data and directly estimate CFD flow fields. This proof-of-concept study used 135 3D cardiac MRIs from both a public and private dataset. The pulmonary arteries in the MRIs were manually segmented and converted into volume-meshes. CFD simulations were performed on ground truth meshes and interpolated onto point-point correspondent meshes to create the ground truth dataset. The dataset was split 110/10/15 for training, validation, and testing. Image2Flow, a hybrid image and graph convolutional neural network, was trained to transform a pulmonary artery template to patient-specific anatomy and CFD values, taking a specific inlet velocity as an additional input. Image2Flow was evaluated in terms of segmentation, and the accuracy of predicted CFD was assessed using node-wise comparisons. In addition, the ability of Image2Flow to respond to increasing inlet velocities was also evaluated. Image2Flow achieved excellent segmentation accuracy with a median Dice score of 0.91 (IQR: 0.86–0.92). The median node-wise normalized absolute error for pressure and velocity magnitude was 11.75% (IQR: 9.60–15.30%) and 9.90% (IQR: 8.47–11.90), respectively. Image2Flow also showed an expected response to increased inlet velocities with increasing pressure and velocity values. This proof-of-concept study has shown that it is possible to simultaneously perform patient-specific volume-mesh based segmentation and pressure and flow field estimation using Image2Flow. Image2Flow completes segmentation and CFD in ~330ms, which is ~5000 times faster than manual methods, making it more feasible in a clinical environment. Author summary: Computational fluid dynamics is an engineering tool that can be used in a clinical setting to non-invasively model blood flow through blood vessels, such as the pulmonary artery. This information can be used to inform treatment planning for patients, especially those with cardiovascular conditions. However, its routine use is limited by a labor-intensive process, requiring substantial expertise and computational resources. Recently, machine learning has offered solutions to automate parts of this process, but no single model has addressed the entire workflow. Therefore, we created Image2Flow, a machine learning model capable of generating a patient-specific representation of a pulmonary artery while predicting blood flow through the vessel. Image2Flow can generate highly accurate pulmonary artery representations and reasonably accurate blood flow predictions. Notably, it performs this whole process in 330ms, which is ~5000x faster than the manual methods. With its speed and accuracy, Image2Flow holds substantial promise for facilitating computational fluid dynamics in clinical settings. [ABSTRACT FROM AUTHOR]