Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity (Updated June 11, 2024).

Neurogliaform cells are a type of GABAergic cortical interneurons that have volume transmission output properties. Their activity and function within cortical circuits are not well understood. This study developed genetic tools to target these neurons and found that their spontaneous activity is positively correlated with locomotion. Silencing these neurons increased spontaneous activity during locomotion and impaired visual responses in other neurons. The contrast-dependent visual response of neurogliaform cells varies with their location in the cortex and is influenced by their morphology and input connectivity. This research highlights the importance of neurogliaform cells in regulating cortical activity and their role in visual stimuli. [Extracted from the article]