Comparative Analysis of Eye Moisture Retention: Carboxy Methyl Cellulose Formulations with and without Additional Excipient Ingredients.

Background Dry eye syndrome (DES) is a common condition characterized by insufficient tear production or excessive tear evaporation, leading to discomfort, visual disturbances, and potential damage to the ocular surface. Carboxy methyl cellulose (CMC) is frequently used in artificial tears for its viscosity and lubricating properties. The addition of glycerin and balanced electrolytes to CMC formulations may enhance moisture retention and support ocular surface health, potentially offering superior relief from DES symptoms. Materials and Methods This study is a randomized, double-blind, controlled trial comparing the efficacy of CMC with glycerin and balanced electrolytes (Group A) versus plain CMC (Group B) in maintaining ocular moisture and alleviating DES symptoms. A total of 100 participants, aged 18-65, were randomized into two groups. The primary outcome was the improvement in Ocular Surface Disease Index (OSDI) scores over eight weeks. Secondary outcomes included changes in tear break-up time (TBUT), Schirmer test results, and patient-reported comfort and satisfaction. Adverse events were also monitored. Results Group A showed significant improvement in TBUT, with mean times increasing from 6±2 seconds at baseline to 11±3 seconds at Week 12, compared to 8±2 seconds in Group B. Schirmer test results indicated greater tear production in Group A, with mean values rising from 7±3 mm at baseline to 12±4 mm at Week 12, versus 9±3 mm in Group B. OSDI scores improved significantly more in Group A, with a mean reduction of 20 points, compared to 12 points in Group B. Participant comfort and satisfaction were higher in Group A throughout the study. Adverse events were similar in both groups, with slightly fewer reported in Group A. Conclusion CMC with glycerin and balanced electrolytes is more effective than plain CMC in improving tear stability, tear production, and patient comfort in DES management, with a comparable safety profile. These findings support the use of additional excipients in enhancing the therapeutic efficacy of artificial tears. [ABSTRACT FROM AUTHOR]