Carbonylative synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones from trifluoroacetimidoyl chlorides and amines based on an activated carbon fiber supported palladium catalyst.

Activated carbon fibers, known for their unique physical and chemical properties, are increasingly utilized in diverse industries, including textiles and fabrics, and can serve as ideal supports of heterogeneous palladium catalysts. An efficient strategy for the preparation of 2-(trifluoromethyl)quinazolin-4(3H)-ones via a three-component carbonylative reaction of trifluoroacetimidoyl chlorides and amines using a heterogeneous activated carbon fiber-supported palladium catalyst has been developed. In contrast to the homogeneous catalytic protocol reported previously, the higher efficiency of the heterogeneous reaction is observed and the Pd/ACFs catalyst could be recycled five times with good stability and slightly decreased catalytic reactivity. [ABSTRACT FROM AUTHOR]