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Bioorthogonal Chemistry at Radboud University: Past, Present and Future.

Authors :
Rutjes, Floris P. J. T.
Bonger, Kimberly M.
Neumann, Kevin
Source :
Synlett; Jul2024, Vol. 35 Issue 11, p1230-1238, 9p
Publication Year :
2024

Abstract

This article provides an overview of the field of bioorthogonal chemistry and its advancements at Radboud University. Bioorthogonal chemistry involves conducting chemical reactions within a biological environment with high selectivity and compatibility. Radboud University has made significant contributions to this field, including the development of strained alkynes and the synthesis of bioorthogonal tools such as BCN and TCO. These tools have been applied in various areas such as chemical biology and materials science. The article also highlights the interdisciplinary nature of research at Radboud University and the importance of synthetic availability in bioorthogonal reagents. The text specifically discusses the use of VBAs in bioorthogonal chemistry, particularly in the IEDDA reaction with tetrazines. The authors found that introducing boronic acid substituents on linear alkenes improved their reactivity in the IEDDA reaction. They also observed that the reactivity of VBAs varied depending on the coordinating substituent on the tetrazine. The authors explored the potential of VBAs in click-to-release chemistry, protein modification, and drug delivery applications. The article emphasizes the collaborative efforts and interdisciplinary approach necessary for advancing bioorthogonal chemistry. [Extracted from the article]

Details

Language :
English
ISSN :
09365214
Volume :
35
Issue :
11
Database :
Complementary Index
Journal :
Synlett
Publication Type :
Academic Journal
Accession number :
177902846
Full Text :
https://doi.org/10.1055/s-0042-1751569