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Urate-lowering agents do not have clinically relevant negative effects on sperm quality and reproductive hormones in men with gout: a prospective open-label cohort study.

Authors :
Li, Changhong
Wang, Yuanyuan
Mu, Rong
Zhao, Jinxia
Yao, Zhongqiang
Zhai, Jiayu
Jin, Yinji
Liu, Rui
Liu, Defeng
Hong, Kai
Jiang, Hui
Zhang, Zhe
Source :
Rheumatology International; Jul2024, Vol. 44 Issue 7, p1245-1253, 9p
Publication Year :
2024

Abstract

Objective: The objective of this study was to analyze and compare the effects of different urate-lowering agents on testicular functions in men with gout in a clinical setting. Methods: In this prospective cohort study (Clinical Trial Registration Number: NCT04213534), a total of 49 male patients aged 18–45 years with gout were enrolled. They were divided into three groups and received treatment with either allopurinol, febuxostat or benzbromarone for a duration of 3 months. Semen parameters, reproductive hormones and biochemical assessments were evaluated at baseline, month 1, and month 3. Results: Overall, 40 individuals (81.6%) completed the follow-up visits. In allopurinol group, there were no significant differences in semen parameters from baseline to month 3. Most of sperm parameters in febuxostat group did not show notable changes, except for a decrease in sperm motility at month 3(33.6%, [22.9–54.3] vs 48.4%, [27.4–67.6], p = 0.033). However, the total motile sperm count did not differ significantly after febuxostat treatment. Surprisingly, administration of benzbromarone resulted in improved sperm concentration (37.19 M/mL, [29.6–69.92] vs 58.5 M/mL, [49.8–116.6], p = 0.001). There were no significant changes observed in sperm DNA integrity and reproductive hormones in the three groups from baseline to month 3. The incidence of adverse events did not differ significantly among the three groups as well. Conclusion: This study is the first to demonstrate that urate-lowering agents, allopurinol and febuxostat, do not have clinically relevant negative effects on sperm quality and reproductive hormones in men with gout, and benzbromarone presents improving sperm concentration. Results provide important preliminary guidance for the development of reproductive health management guidelines for patients RCID with gout. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01728172
Volume :
44
Issue :
7
Database :
Complementary Index
Journal :
Rheumatology International
Publication Type :
Academic Journal
Accession number :
177898352
Full Text :
https://doi.org/10.1007/s00296-024-05572-x