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Medication Risks and Their Association with Patient-Reported Outcomes in Inpatients with Cancer.
- Source :
- Cancers; Jun2024, Vol. 16 Issue 11, p2110, 14p
- Publication Year :
- 2024
-
Abstract
- Simple Summary: Most cancer patients are older and have concomitant diseases because the incidence of most cancer types increases with age. This leads to patients taking a variety of medications that can cause drug-related problems (DRPs). DRPs can cause harm, including increased illness, avoidable hospital stays, and even death. Common DRPs are drug–drug interactions, not taking medication as prescribed, and adverse drug reactions. In our study, we aimed to assess these medication risks in hospitalized cancer patients and to identify factors that influence their health-related quality of life (HRQOL) as a patient-relevant outcome. The results of the pharmacist-led medication reviews show that DRPs are common in hospitalized cancer patients. Therefore, patient questionnaires about therapy-related symptoms could improve the detection of DRPs. While drug-related factors had no effect on HRQOL during the hospital stay, our analysis revealed other influencing factors, such as relapse status of the cancer disease and length of hospital stay. Background: We aimed to assess medication risks and determine factors influencing the health-related quality of life (HRQOL) in cancer inpatients. Methods: A retrospective analysis was conducted to identify drug-related problems (DRPs) based on medication reviews, including patient-reported outcomes (PROs). Multiple linear regression analyses were performed to identify sociodemographic, disease-related, and drug therapy-related factors influencing changes from hospital admission to discharge in the scales of the EORTC QLQ-C30 questionnaire. Results: A total of 162 inpatients with various hematological and solid cancer diseases was analyzed. Patients received a mean of 11.6 drugs and 92.6% of patients exhibited polymedication resulting in a mean of 4.0 DRPs per patient. Based on PRO data, 21.5% of DRPs were identified. Multiple linear regression models described the variance of the changes in global HRQOL and physical function in a weak-to-moderate way. While drug therapy-related factors had no influence, relapse status and duration of hospital stay were identified as significant covariates for global HRQOL and physical function, respectively. Conclusion: This analysis describes underlying DRPs in a German cancer inpatient population. PROs provided valuable information for performing medication reviews. The multiple linear regression models for global HRQOL and physical function provided explanations for changes during hospital stay. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISK assessment
BIOLOGICAL models
DRUG side effects
PATIENTS
HEMATOLOGIC malignancies
CANCER relapse
RESEARCH funding
HOSPITAL care
MULTIPLE regression analysis
HOSPITAL admission & discharge
QUESTIONNAIRES
CANCER patient medical care
MEDICATION error prevention
PATIENT care
RETROSPECTIVE studies
DISCHARGE planning
DESCRIPTIVE statistics
CANCER patients
QUALITY of life
MEDICAL records
ACQUISITION of data
TUMORS
HEALTH outcome assessment
SOCIODEMOGRAPHIC factors
LENGTH of stay in hospitals
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 16
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 177874188
- Full Text :
- https://doi.org/10.3390/cancers16112110