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Serum-Derived Bovine Immunoglobulin Promotes Barrier Integrity and Lowers Inflammation for 24 Human Adults Ex Vivo.

Authors :
Van den Abbeele, Pieter
Kunkler, Charlotte N.
Poppe, Jonas
Rose, Alexis
van Hengel, Ingmar A. J.
Baudot, Aurélien
Warner, Christopher D.
Source :
Nutrients; Jun2024, Vol. 16 Issue 11, p1585, 18p
Publication Year :
2024

Abstract

Serum-derived bovine immunoglobulin (SBI) prevents translocation and inflammation via direct binding of microbial components. Recently, SBI also displayed potential benefits through gut microbiome modulation. To confirm and expand upon these preliminary findings, SBI digestion and colonic fermentation were investigated using the clinically predictive ex vivo SIFR<superscript>®</superscript> technology (for 24 human adults) that was, for the first time, combined with host cells (epithelial/immune (Caco-2/THP-1) cells). SBI (human equivalent dose (HED) = 2 and 5 g/day) and the reference prebiotic inulin (IN; HED = 2 g/day) significantly promoted gut barrier integrity and did so more profoundly than a dietary protein (DP), especially upon LPS-induced inflammation. SBI also specifically lowered inflammatory markers (TNF-α and CXCL10). SBI and IN both enhanced SCFA (acetate/propionate/butyrate) via specific gut microbes, while SBI specifically stimulated valerate/bCFA and indole-3-propionic acid (health-promoting tryptophan metabolite). Finally, owing to the high-powered cohort (n = 24), treatment effects could be stratified based on initial microbiota composition: IN exclusively stimulated (acetate/non-gas producing) Bifidobacteriaceae for subjects classifying as Bacteroides/Firmicutes-enterotype donors, coinciding with high acetate/low gas production and thus likely better tolerability of IN. Altogether, this study strongly suggests gut microbiome modulation as a mechanism by which SBI promotes health. Moreover, the SIFR<superscript>®</superscript> technology was shown to be a powerful tool to stratify treatment responses and support future personalized nutrition approaches. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
16
Issue :
11
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
177868834
Full Text :
https://doi.org/10.3390/nu16111585