New Malaria Research Study Results from University of Groningen Described (Small-molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells).

A recent research study conducted at the University of Groningen in the Netherlands has identified small-molecule allosteric inhibitors of human aspartate transcarbamoylase (ATC) that can suppress the proliferation of bone osteosarcoma epithelial cells. ATC is an enzyme involved in the first step of pyrimidine biosynthesis, and inhibiting this pathway has been proposed as a potential target for suppressing cell proliferation in various diseases, including malaria, tuberculosis, and cancer. The researchers screened a library of ATC inhibitors and identified four compounds that showed significant inhibition of human ATC in vitro. These compounds also demonstrated the ability to suppress the proliferation of osteosarcoma cells. The study provides evidence for the existence of an allosteric pocket in human ATC, which enhances its potential as a target for cancer therapy. [Extracted from the article]