Editorial: Molecular mechanisms of resistance to "last resort" antimicrobials in Enterobacterales.

This article explores the molecular mechanisms behind the resistance to "last resort" antimicrobials in Enterobacterales. It discusses how the use and misuse of antibiotics in various fields have led to the emergence of bacterial strains that are resistant to multiple antibiotics. The focus is on resistance to carbapenem, colistin, and tigecycline, which are considered last-resort antibiotics. The article also highlights specific cases of outbreaks and the challenges faced by clinicians in treating multidrug-resistant infections. It mentions the potential transmission of resistant strains between animals and humans and emphasizes the importance of continued genomic surveillance and strict antibiotic stewardship to protect these last-resort antibiotics. [Extracted from the article]