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Health-related quality of life and associated risk factors in patients with Multiple Osteochondromas: a cross-sectional study.

Authors :
Boarini, Manila
Tremosini, Morena
Di Cecco, Alessia
Gnoli, Maria
Brizola, Evelise
Mordenti, Marina
Pedrini, Elena
Locatelli, Manuela
Lanza, Marcella
Antonioli, Diego
Gallone, Giovanni
Rocca, Gino
Staals, Eric L.
Trisolino, Giovanni
Sangiorgi, Luca
Source :
Quality of Life Research; May2024, Vol. 33 Issue 5, p1323-1334, 12p
Publication Year :
2024

Abstract

Purpose: To evaluate the health-related quality of life and associated risk factors for Multiple Osteochondromas patients. Methods: A cross-sectional, observational study was conducted from May to December 2022 during the routine visit to the referral center for rare skeletal disorders. All patients with Multiple Osteochondromas aged ≥ 3 years were included. EuroQol 5-dimension questionnaires, and demographic, clinical, and surgical history data were collected. Descriptive statistics, Fisher's exact test, One-sample t-test, Spearman's correlation, and multiple linear and logistic regression were performed to analyze the data. Results are reported following STROBE guidelines. Results: A total of 128 patients were included in the study, with a mean age of 14 [SD, 10] years. The mean EQ-5D Index Value was 0.863 [SD, 0.200] and the EQ-VAS was 84 [SD, 19] with a positive correlation between two scores [r = 0.541, p < 0.001]. Patients frequently referred problems in pain/discomfort [78.8%], anxiety/depression [50%], and usual activities [38.8%] dimensions. Increasing age was the common risk factor for health-related quality of life [p < 0.000], as well as Index Value and VAS scores were significantly lower in surgical patients [p = 0.001 and p < 0.001, respectively]. Conclusion: Increasing age and surgical procedures were found highly associated with reduced health-related quality of life in Multiple Osteochondromas patients. Our findings provide relevant information to support the establishment of patient-centered healthcare pathways and pave the way for further research into medical and non-medical therapeutic strategies for these patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09629343
Volume :
33
Issue :
5
Database :
Complementary Index
Journal :
Quality of Life Research
Publication Type :
Academic Journal
Accession number :
177776366
Full Text :
https://doi.org/10.1007/s11136-024-03604-4