Back to Search Start Over

Late genitourinary toxicity in salvage radiotherapy for prostate cancer after radical prostatectomy: impact of daily fraction doses.

Authors :
Takano, Seiya
Tomita, Natsuo
Takaoka, Taiki
Niwa, Masanari
Torii, Akira
Kita, Nozomi
Okazaki, Dai
Uchiyama, Kaoru
Nakanishi-Imai, Mikiko
Ayakawa, Shiho
Iida, Masato
Tsuzuki, Yusuke
Otsuka, Shinya
Manabe, Yoshihiko
Nomura, Kento
Ogawa, Yasutaka
Miyakawa, Akifumi
Miyamoto, Akihiko
Takemoto, Shinya
Yasui, Takahiro
Source :
British Journal of Radiology; May2024, Vol. 97 Issue 1157, p1050-1056, 7p
Publication Year :
2024

Abstract

Objective To evaluate the impact of daily fraction doses on late genitourinary (GU) toxicity after salvage radiotherapy (SRT) for prostate cancer. Methods This multi-institutional retrospective study included 212 patients who underwent SRT between 2008 and 2018. All patients received image-guided intensity-modulated SRT at a median dose of 67.2 Gy in 1.8-2.3 Gy/fraction. The cumulative rates of late grade ≥2 GU and gastrointestinal (GI) toxicities were compared using Gray test, stratified by the ≤2.0 Gy/fraction (n  =   137) and ≥2.1 Gy/fraction groups (n  =   75), followed by multivariate analyses. The total dose was represented as an equivalent dose in 2-Gy fractions (EQD2) with α/β = 3 Gy. Results After a median follow-up of 63 months, the cumulative rates of 5-year late grade ≥2 GU and GI toxicities were 14% and 2.5%, respectively. The cumulative rates of 5-year late grade ≥2 GU toxicity in the ≥2.1 Gy/fraction and ≤2.0 Gy/fraction groups were 22% and 10%, respectively (P  =  .020). In the multivariate analysis, ≥2.1 Gy/fraction was still associated with an increased risk of late grade ≥2 GU toxicity (hazard ratio, 2.37; 95% confidence interval, 1.12-4.99; P  =  .023), while the total dose was not significant. Conclusion The present results showed that ≥2.1 Gy/fraction resulted in a higher incidence of late grade ≥2 GU toxicity in SRT. Advances in knowledge The impact of fraction doses on late GU toxicity after SRT remains unknown. The results suggest that higher fraction doses may increase the risk of late GU toxicity in SRT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00071285
Volume :
97
Issue :
1157
Database :
Complementary Index
Journal :
British Journal of Radiology
Publication Type :
Academic Journal
Accession number :
177717971
Full Text :
https://doi.org/10.1093/bjr/tqae055