TIF1g regulates stability of T regulatory cells during inflammation.

A preprint abstract from biorxiv.org discusses the role of TIF1g in regulating the stability of T regulatory cells (Tregs) during inflammation. Tregs are important for controlling inflammation and maintaining tissue homeostasis. The study found that TIF1g-deficient Tregs lose stability and acquire an effector phenotype in the presence of inflammation or upon activation. The absence of TIF1g also led to increased methylation in the Foxp3 locus, suggesting a higher susceptibility for loss of Foxp3 expression. The beta-catenin pathway was identified as the molecular mechanism driving TIF1g-dependent Treg stability and proliferation during inflammation. This research provides insights into the modulation of Treg cells for therapeutic purposes. [Extracted from the article]