Researcher from Karolinska Institute Discusses Findings in Human Papillomavirus Vaccines (Low methylation marker levels among human papillomavirus-vaccinated women with cervical high-grade squamous intraepithelial lesions).

A recent study conducted by researchers at the Karolinska Institute examined the use of methylation markers in cervical cancer screening programs for women who have received the human papillomavirus (HPV) vaccine. The study found that methylation levels were generally low among HPV-vaccinated women with high-grade squamous intraepithelial lesions (HSIL), and no significant differences were observed in methylation levels of viral or host-cell genes between HSIL cases and controls. However, a significant difference in methylation levels was found when considering a combination of viral genes and EPB41L3. Further investigation is needed to understand the implications of these findings for the management of HSIL in HPV-vaccinated women. [Extracted from the article]