Tianjin Children's Hospital Reports Findings in Acute Disseminated Encephalomyelitis (Novel Genetic Variants Distinguishing Myelin Oligodendrocyte Glycoprotein-IgG-Positive From Myelin Oligodendrocyte Glycoprotein-IgG-Negative Pediatric Acute...).

A report from Tianjin Children's Hospital in China discusses a study on acute disseminated encephalomyelitis (ADEM), a common condition in children with myelin oligodendrocyte glycoprotein IgG (MOG-IgG)-associated disease. The researchers aimed to identify genetic variants that distinguish between MOG-IgG-positive ADEM and MOG-IgG-negative ADEM. Through whole exome sequencing analysis, they identified three variants (rs11171951 in NACa, rs231775 in CTLA4, and rs11171951 in GOLGA5) that were significantly different between the two groups. These findings suggest that these variants may serve as novel genetic risk factors for distinguishing between MOG-IgG-positive and MOG-IgG-negative ADEM in a Han Chinese population. [Extracted from the article]