Departamento de Anestesiologia Reports Findings in Health and Medicine (Comparison of intranasal dexmedetomidine versus oral midazolam for premedication in pediatric patients: an updated meta-analysis with trial-sequential analysis).

A recent study conducted in Rio de Janeiro, Brazil compared the effectiveness and safety of two common routes of administration for premedication in pediatric patients: oral midazolam and intranasal dexmedetomidine. The study found that there was no difference in satisfactory induction or mask acceptance between the two medications. However, dexmedetomidine was associated with a higher incidence of satisfactory separation from parents and a lower incidence of emergence agitation. The researchers concluded that intranasal dexmedetomidine may be a safe and effective alternative to oral midazolam for premedication in pediatric patients. [Extracted from the article]