Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation.

According to a preprint abstract from biorxiv.org, researchers have found that the stearoyl coenzyme A desaturase 1 (SCD1) enzyme plays a role in regulating the replication of the foot-and-mouth disease virus (FMDV) by modulating host cell lipid metabolism and the formation of replication complexes. The study showed that overexpression of SCD1 or the addition of oleic acid (OA), a product of SCD1 activity, increased FMDV replication in certain cells. Inhibition of SCD1 activity also suppressed replication of other positive-sense RNA viruses. These findings suggest that SCD1 could be a potential target for developing drugs against positive-sense RNA virus infections. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]