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Dietary restriction in senolysis and prevention and treatment of disease.
- Source :
- Critical Reviews in Food Science & Nutrition; 2024, Vol. 64 Issue 16, p5242-5268, 27p
- Publication Year :
- 2024
-
Abstract
- Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. This has sparked interest in the use of dietary regimens as a non-pharmacological means to slow aging and prevent disease. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10408398
- Volume :
- 64
- Issue :
- 16
- Database :
- Complementary Index
- Journal :
- Critical Reviews in Food Science & Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 177672880
- Full Text :
- https://doi.org/10.1080/10408398.2022.2153355