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Juvenile Granulosa Cell Tumor Mimicking HAIR-AN in a 4-yearold: A Case Report.
- Source :
- Journal of Clinical Research in Pediatric Endocrinology; Jun2024, Vol. 16 Issue 2, p200-204, 5p
- Publication Year :
- 2024
-
Abstract
- Predominantly androgen secreting juvenile granulosa cell tumors (JGCT) are uncommon and few reports have been published. We present a case of a JGCT that presented with signs of prepubertal hyperandrogenism and insulin resistance to highlight the possible interaction between hyperandrogenemia and hyperinsulinism. A 4-year-old girl presented with acanthosis nigricans and hyperinsulinism, mimicking the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome at an age much younger than is typical for this diagnosis. Laboratory studies revealed elevated insulin, inhibin A and B, and total testosterone. All laboratory results normalized after unilateral salpingo-oophorectomy. The final diagnosis was Stage 1A JGCT. This case highlights the importance of including ovarian tumors in the differential diagnosis when considering causes of virilization and insulin resistance. This case also suggests a potential relationship between excess testosterone secretion and hyperinsulinemia and strengthens evidence that hyperandrogenemia may promote hyperinsulinism in ovarian disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- TESTOSTERONE
SEX hormones
PROGESTERONE
PHYSICAL diagnosis
HYPERTRICHOSIS
PELVIS
SALPINGO-oophorectomy
GRANULOSA cell tumors
HYPERANDROGENISM
COMPUTED tomography
HYPERINSULINISM
POLYCYSTIC ovary syndrome
TREATMENT effectiveness
LACTATE dehydrogenase
INSULIN resistance
HEMOCHROMATOSIS
CLINICAL pathology
MELANOSIS
HEALTH care teams
SYMPTOMS
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 13085727
- Volume :
- 16
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 177615452
- Full Text :
- https://doi.org/10.4274/jcrpe.galenos.2022.2022-4-17