Patent Issued for Compositions and methods for inhibiting viral vector-induced inflammatory responses (USPTO 11981911).

A patent has been issued for compositions and methods that inhibit viral vector-induced inflammatory responses in gene therapy. The patent describes viral molecular therapy vectors that prevent the production of proinflammatory cytokines while increasing the expression of therapeutic genes. These vectors can be administered intramuscularly, intravenously, or intravitreally. The patent also includes methods for making recombinant viral genomes and administering them to subjects in need. The inventors of the patent are Ying Kai Chan and George M. Church, and the assignee is the President and Fellows of Harvard College. [Extracted from the article]