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BIOLOGICAL ASPECTS OF NEW MOLECULAR THERAPIES FOR NEUROPATHOLOGIES.
- Source :
- Medical Science Pulse; 2024 Supplement, Vol. 18, p39-39, 1p
- Publication Year :
- 2024
-
Abstract
- Introduction: Addressing the formidable therapeutic hurdles posed by Alzheimer's disease (AD), our study delves into the central role of amyloid β 1-42 (Aβ1-42) protein aggregation in its onset. Aim: Our investigation aims to assess the therapeutic potential of the isoindolinone derivative 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) against the Aβ1-42-induced toxicity. Material and methods: Employing a combination of thioflavin T fluorescence assay and biological and cellular approaches, alongside other experimental methods, we explored ISOAC1's ability to mitigate Aβ1-42 aggregation and toxicity. Results and conclusions: Our study unveils ISOAC1's capacity to disrupt Aβ1-42 aggregation and impede its transition towards β-sheet structures. Furthermore, our findings shed light on ISOAC1's binding mechanisms with Aβ1-42, indicating its promise as a therapeutic agent. ISOAC1 emerges as a compelling neuroprotective compound, offering novel avenues for AD treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALZHEIMER'S disease
BIOLOGICAL assay
NEUROLOGICAL disorders
THIOFLAVINS
Subjects
Details
- Language :
- English
- ISSN :
- 25441558
- Volume :
- 18
- Database :
- Complementary Index
- Journal :
- Medical Science Pulse
- Publication Type :
- Academic Journal
- Accession number :
- 177543268