Improving rigor and reproducibility in cardiovascular research.

This document is an editorial that emphasizes the importance of rigor and reproducibility in cardiovascular research. It discusses the need for improving methods and models, incorporating sex as a biological variable, and testing assumptions in order to enhance the reliability and replicability of research. The document provides practical recommendations and protocols for standardizing data collection and analysis, quantifying diastolic dysfunction, and assessing the impact of factors such as sex and assumptions on research outcomes. It also highlights the responsibility of researchers to produce precise and accurate research to maintain the reputation of the cardiovascular physiology community. Funding acknowledgments and author contributions are included. [Extracted from the article]