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Serum sclerostin as a biomarker of disease activity in ankylosing spondylitis in correlation with radiographic imaging.
- Source :
- Egyptian Rheumatology & Rehabilitation; 5/23/2024, Vol. 51 Issue 1, p1-6, 6p
- Publication Year :
- 2024
-
Abstract
- Background: The wingless signaling pathway of bone development is inhibited by sclerostin, which may contribute to the etiology of ankylosing spondylitis. Aim: The study aimed to evaluate serum sclerostin levels in ankylosing spondylitis patients and investigate how it correlated with radiographic damage using the Spondylo-arthritis Research Consortium of Canada index (SPARCC), disease activity, and functional impairment. Results: This cross-sectional case–control study revealed a significantly lower mean serum sclerostin (11.28 ng/ml) in AS patients compared with controls (101.25 ng/ml). Serum sclerostin levels showed a significant negative correlation with each of Bath Ankylosing Spondylitis Metrology Index (BASMI) (p = 0.043), sacroiliac joints SPARCC, spine SPARCC, and overall SPARCC scores (p = 0.012, p = 0.036, and p = 0.007). The detection of AS, serum sclerostin levels ≤ 20 ng/ml showed 100% sensitivity and specificity. Conclusion: Serum sclerostin had good discriminating power between ankylosing spondylitis cases and healthy control individuals and was correlated with subclinical activity status on magnetic resonance imaging. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANKYLOSING spondylitis
MEN
STATISTICAL correlation
CROSS-sectional method
PEARSON correlation (Statistics)
T-test (Statistics)
QUALITATIVE research
RECEIVER operating characteristic curves
ENZYME-linked immunosorbent assay
GLYCOPROTEINS
FUNCTIONAL status
CELLULAR signal transduction
MAGNETIC resonance imaging
BLOOD sedimentation
BLOOD cell count
DESCRIPTIVE statistics
CHI-squared test
RESEARCH
CASE-control method
COMPARATIVE studies
DATA analysis software
BIOMARKERS
SENSITIVITY & specificity (Statistics)
DISEASE progression
C-reactive protein
Subjects
Details
- Language :
- English
- ISSN :
- 1110161X
- Volume :
- 51
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Egyptian Rheumatology & Rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 177466455
- Full Text :
- https://doi.org/10.1186/s43166-024-00258-5